Baseline serum aldosterone was strongly associated with the development of hypertension during a 4-year follow-up, independent of renin-angiotensin II.
Hyperaldosteronism is significantly associated with the development, severity, and treatment resistance of hypertension, independent of renin activity.
A growing body of evidence suggests that hyperaldosteronism contributes significantly to the development and the severity of hypertension as well as to resistance to antihypertensive treatment. In cross-sectional analyses, plasma aldosterone levels have been shown to relate to BP levels, particularly in obese individuals. In these same individuals, BP was not related to plasma renin activity, suggesting an effect of aldosterone on BP independent of renin-angiotensin II. In a recent prospective analysis from the Framingham investigators, baseline serum aldosterone was strongly associated with development of hypertension during a 4-yr follow-up.
David A. Calhoun (Thu,) conducted a review in Hypertension. Aldosterone was evaluated on Development of hypertension. Baseline serum aldosterone was strongly associated with the development of hypertension during a 4-year follow-up, independent of renin-angiotensin II.
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