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Over the last hundred years, the diagnosis of hypertension has rested upon the indirect measurement of blood pressure (BP) through the auscultation of Korotkoff sounds. Among patients on haemodialysis, BP measurement is particularly important because disparate outcomes are obtained depending on the timing, location, frequency and technique of measurement of BP 1. This disparity of outcomes has profound implications for the management of hypertension especially among haemodialysis patients. Why home BP monitoring should become the standard of care among patients on haemodialysis is the subject of this review. To compare tests, such as one that tests home BP to pre-dialysis BP, a diagnostic test study must be performed. A diagnostic test study can have one of the following four paradigms (Figure 1): Test A (e.g. home BP) is compared to test B (e.g. pre-dialysis BP) using a ‘gold-standard’ or reference test. If test A performs better than test B, then test A is preferred. Whether test A should be favoured over test B depends on a variety of considerations such as its cost, practicality, invasiveness and acceptability. The two tests may be compared not to a reference standard but to some intermediate end point. A valid intermediate end point among hypertensive patients is the presence of target organ damage such as left ventricular hypertrophy. In other words, home BP can be compared to pre- or post-dialysis BP and the results compared in their ability to predict echocardiographic left ventricular hypertrophy. If home BP measurement is more strongly related to target organ damage then, compared to paradigm 1, it provides a higher level of evidence that it is superior to pre-dialysis or post-dialysis BP. The two tests can be compared with respect to prognosis, for example, all-cause mortality. For example, with respect to outcomes such as all-cause mortality, dialysis unit BP measurements can be compared to home BP measurements. If home BP measurement is more strongly related to all-cause mortality then, compared to paradigm 2, it provides even a higher level of evidence that it is superior to pre-dialysis or post-dialysis BP. Finally, a randomized controlled trial can be performed to assess the value of a diagnostic test. For example, management of the patient based on home BP monitoring vs dialysis unit BP measurements can be compared in a randomized trial. If the outcomes are better with home BP monitoring, then home BP monitoring would be said to be superior. The outcomes can be one of three outcomes: the reference test, in this case ambulatory BP, regression of left ventricular hypertrophy or improvement in all-cause mortality. This paradigm would provide the highest level of evidence of the superiority of home BP recordings over dialysis unit BP recordings. Relative strength of evidence of superiority of test A vs test B. This review will focus on the data which support the use of out-of-office BP monitoring among patients on haemodialysis. The use of out-of-office BP monitoring among patients with chronic kidney disease who are not on haemodialysis is discussed elsewhere 2. The feasibility of home BP monitoring among haemodialysis patients was reported in just 20 patients more than a decade ago 3; substantial refinements have been made since then. Agarwal and Lewis compared pre-dialysis and post-dialysis BP measurements to ambulatory BPs 4. The area under the curve of the receiver operating characteristic (ROC) curve, though acceptable, was not good enough for clinical decision making. There was no threshold at which there was sufficient sensitivity and specificity to diagnose ambulatory hypertension. Furthermore, they found wide agreement limits between pre- and post-BP measurement as compared to ambulatory BP. Accordingly, they concluded that pre- and post-dialysis BP measurements can be useful in a qualitative sense but are not useful quantitatively. These results were subsequently supported by a meta-analysis that demonstrated that pre- and post-dialysis BP measurements are inadequate surrogates of ambulatory BPs 5. The pre-dialysis BP measurement, in this meta-analysis, overestimated ambulatory BP by over 16.7 mm Hg. However, the agreement limits were wide. Even for post-dialysis BP, a measurement which was less biased compared to pre-dialysis measurements, the agreement limits were wide. Accordingly, pre- and post-dialysis BP measurements were not held to be valid surrogates of ambulatory BPs at the patient level. BP recorded in the above studies was not measured using any specified technique; these were ‘routine’ BP recordings. Rahman et al. have reported that BP measured using routine methods can be quite different compared to those obtained by using a proper technique 6. In 55% of patients, the post-dialysis systolic BP measured in the dialysis unit was at least 10 mm Hg higher than the standard reading. Thus, routine and standardized readings could not be used interchangeably. To address these issues, in a subsequent study, Agarwal et al. measured BP using a standardized technique wherein BPs were recorded in triplicate before and after dialysis for six consecutive dialysis treatments 7. They then compared pre- and post-dialysis BP measurements by both routine and standardized methods and home BP measurement to the reference standard of ambulatory BP monitoring. The area under the curve of the ROC curve for home BP was 0.89. Thus, if home BP monitoring was used to make clinical decisions regarding the presence or absence of hypertension in this unselected population of haemodialysis patients, the correct diagnosis would be reached 89% of the time. The threshold of 150 mm Hg systolic had the optimal sensitivity and specificity for diagnosed hypertension. Sensitivity at this threshold was 80% and specificity 84%. However, pre- and post-dialysis BP measurements regardless of routine or standardized measurement methods did not share this optimal combination of sensitivity and specificity. Thus, a threshold BP at which there would be an acceptable classification of patients into normotensive and hypertensive groups was not achieved using dialysis unit BP recordings. Accordingly, even averaged standardized BP measurement compared to home BP recordings does not share an adequate combination of sensitivity and specificity to be useful for diagnosing hypertension. Rohrscheib et al. have recently reported that the variability of BP recorded before and after dialysis between patients is as much as the variability of BP within patients 8. Their results from a US dialysis chain were based on a large number of recordings. Despite these large numbers of measurements, the intra-class correlation coefficients of pre-dialysis or post-dialysis BPs were not deemed clinically useful to make diagnostic decisions. Agarwal et al. reported the value of pre-dialysis, post-dialysis, home BP and ambulatory BP measurement in diagnosing left ventricular hypertrophy 9. Left ventricular hypertrophy was taken as evidence of target organ damage among hypertensive haemodialysis patients. They found that home and ambulatory BPs were equally good in predicting left ventricular hypertrophy. Out-of-dialysis unit BP measurements such as pre- or post-dialysis BPs even when obtained using a standardized BP measurement technique were not useful in detecting the presence of left ventricular hypertrophy. Reports from Japan using weekly average BPs, using a combination of home BP measurements as well as dialysis unit BP measurements, suggest that the weekly averages have a stronger relationship with left ventricular hypertrophy and pulse wave velocity 10. Thus, when target organ damage is used as an outcome variable, these results underscore the superiority of home BP measurements over dialysis unit BP. Alborzi et al. compared pre-dialysis, post-dialysis BPs, home BPs and ambulatory BPs in predicting all-cause and cardiovascular mortality among 150 patients who were followed for a median of 2 years 11. They found that ambulatory BPs had the best relationship between the level of systolic BP and outcomes. Home BPs were next most useful in predicting all-cause mortality. A dose–response relationship between increasing quartiles of both home BP and ambulatory BP and all-cause mortality and cardiovascular mortality was seen. However, pre- or post-dialysis BP measurements were not useful in predicting all-cause or cardiovascular mortality. Subsequently, Moriya et al. reported that among haemodialysis patients single measurements of pre-dialysis BP recording were insufficient to predict cardiovascular events or all-cause mortality 12. However, weekly averaged BP was noted to be an independent prognostic marker. Agarwal, in a recent study of 326 haemodialysis patients followed for up to 7 years, reported that only home and ambulatory BPs were useful for predicting all-cause mortality 13. A dose–response relationship between systolic BP and mortality was seen. Pre- and post-dialysis BP measurements were not useful in predicting outcomes. A complex relationship between BP and outcomes emerged. At very low BPs, 10% and is associated with more target organ damage and adverse outcomes 29,30. However, more sophisticated, albeit more complex, recognition of patterns is possible using circular statistics. Statistically, using the trended cosinor model, these patterns can be described by an intercept, slope, amplitude and a phase 31. The phase at the time of maximal BP is called the acrophase and the time of minimum BP is called the bathyphase. The significance of these patterns is discussed further. The intercept BP is related to the number of medications; the greater the number of medications the higher the intercept 31. This probably indicates confounding by indication. Those patients who have the highest BPs are exposed to the highest number of medications. The intercept is also associated with increased aortic stiffness 32. The aortic stiffness measured by aortic pulse wave velocity was elevated in patients who had highest BPs 32. With improvement in dry weight, the intercept BP was reduced which suggests that the intercept BP can be modulated by changes in volume state 33. The slope of the BP is also related to the volume state 33. In patients who had dry-weight reduction, steeper slopes were seen. Conversely, blunted slopes may indicate volume excess. Indeed, a higher number of medications are associated with blunter slopes indicating that latent volume overload may be treated with medications 31. High interdialytic weight gain may also lead to steeper slopes 32. Again, sodium restriction may potentially reduce the slopes and therefore improve overall BP. The phase and amplitude of BP variation may indicate the phenomena of dipping. Dipping was not restored in the DRIP trial by proving dry weight indicating that dipping may be related to factors other than volume 28–33. Structural and functional alterations of the conduit blood vessels are thought to contribute to the morbidity and mortality among haemodialysis patients, and various techniques have been applied to detect these alterations 34. Although augmentation index is useful to assess pulse reflection, the aortic to femoral pulse wave velocity is held to be the reference standard for the measurement of arterial stiffness. The mechanical properties of the aorta are profoundly altered even among children on haemodialysis 35. But despite the high prevalence of arterial stiffness, not all studies find that it is related to outcomes 36. Perhaps the serial measurement of arterial mechanics can serve as an important prognostic tool to assess the effectiveness of anti-hypertensive therapy among hypertensive haemodialysis patients 37. There are several uncertainties that exist in the assessment of hypertension. Davenport et al. reported that there was an increased frequency of intradialytic hypotension when dialysis units in London tried to achieve the guideline recommended goals using pre- and post-dialysis BP 38. Whether home BP guided therapies will reduce these episodes of intradialytic hypotension is unclear. No study has definitively shown whether BP reduction is causally associated with an improvement in cardiovascular or mortal outcomes among dialysis patients. Although two recent meta-analyses indicate that anti-hypertensive therapies are useful, no single trial has proven this 39,40. Furthermore, it is unclear as to what the targets are for BP lowering. A large simple trial that explores the hypothesis whether BP should be lowered among hypertensive haemodialysis patients needs to be conducted. Such a trial would explore different levels of BP control. BP control would be guided not by pre-dialysis and post-dialysis measurements but by home BP monitoring. Without such a trial, despite the two meta-analyses, we will not have robust data to lower BP among hypertensive haemodialysis patients 41. In the absence of randomized controlled trial data, from observational studies, it appears that home BP-guided management of anti-hypertensive drug and non-drug therapy in the 120–140 mm Hg range may be useful. It is also not entirely clear why out-of-dialysis unit BP measurements have greater prognostic significance. Several reasons are possible why ambulatory or home BP may be superior to dialysis unit recordings which include the following: greater number of measurements, sampling over a wide variety of volume and uraemic states, sampling over periods of rest and activity and possibly a better measurement technique. Despite uncertainties, the American Heart Association 42 and European Society of Hypertension 43 both recommend that in all patients with hypertension home BP monitoring should be performed. The studies discussed above suggest that home BP monitoring can be successfully used to make management decisions among haemodialysis patients. National health organizations and insurance companies should pay for the equipment, training and time required for home BP monitoring among haemodialysis patients. These measurements would allow the detection of volume overload and hypertension that has the potential to translate to better outcomes in these vulnerable patients. The time to act is now! Conflict of interest statement. None declared. This study is dedicated to the memory of Dr Thomas G. Pickering, a leading hypertension expert of our times, who arguably was among the most ardent supporters of home BP monitoring. This study was supported by National Institutes of Health (2RO1-062030-06).
Rajiv Agarwal (2010) studied this question.