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The specific antagonism of some actions of histamine by low concentrations of anti- histamine drugs characterizes one type of histamine receptor for which we suggest the symbol H. Such receptors occur in guinea-pig ileum and bronchi Several other actions of histamine, for example, stimulation of gastric acid secretion, inhibition of rat uterus and stimulation of isolated atria, cannot be specifically antagonized These actions are likely to be mediated by other histamine receptors.
Ash et al. (Mon,) studied this question.