An automated short time Fourier Transform algorithm detected functional conduction block during ventricular fibrillation from a single electrode recording with a sensitivity of 0.74 ± 0.12 and specificity of 0.99 ± 0.00.
UNLABELLED: It is commonly thought that lethal tachyarrhythmias, such as ventricular fibrillation (VF), are perpetuated by functional reentry, which occurs when an activation wave blocks and rotates around tissue that is excitable (i.e., functional block). Electrograms recorded near these regions typically contain two sequential deflections representing activation on either side of the block. By detecting these "double potentials," we hypothesize that functional block can be detected by a single electrode. METHODS: Unipolar electrograms were recorded from a 24 x 21 mapping array on the intact ventricular epicardium of five pigs during electrically-induced VF. The short time Fourier Transform (STFT) of each electrogram was analyzed to identify double potentials. To evaluate the performance of the STFT algorithm, conduction block was located in activation maps using a minimum conduction velocity criterion (10 cm/s) and then compared to the results of the STFT algorithm. RESULTS: The STFT algorithm detected conduction block with a sensitivity of 0.74 +/- 0.12 and a specificity of 0.99 +/- 0.00. CONCLUSION: We have developed an automated algorithm that can detect functional block during VF from a single electrode recording. Possible applications include fast, objective identification of block in mapping data and realtime localization of reentrant substrates using mapping catheters.
Evans et al. (Fri,) conducted a other in Ventricular fibrillation (n=5). Short time Fourier Transform (STFT) algorithm vs. Activation maps using a minimum conduction velocity criterion (10 cm/s) was evaluated on Detection of conduction block (sensitivity and specificity). An automated short time Fourier Transform algorithm detected functional conduction block during ventricular fibrillation from a single electrode recording with a sensitivity of 0.74 ± 0.12 and specificity of 0.99 ± 0.00.