High fatigue scores in patients undergoing hemodialysis independently predicted a significantly higher risk for fatal or nonfatal cardiovascular events (HR 2.17) compared to normal fatigue scores.
Cohort (n=788)
Yes
Does a high fatigue score predict fatal or nonfatal cardiovascular events in patients undergoing hemodialysis?
Self-reported fatigue is a significant and independent predictor of future cardiovascular events in hemodialysis patients, highlighting its potential utility as a clinical bio-alarm.
Effect estimate: HR 2.17 (95% CI 1.23-3.85)
p-value: p=0.008
BACKGROUND AND OBJECTIVES: Despite potential significance of fatigue and its underlying components in the occurrence of cardiovascular diseases, epidemiologic data showing the link are virtually limited. This study was designed to examine whether fatigue symptoms or fatigue's underlying components are a predictor for cardiovascular diseases in high-risk subjects with ESRD. DESIGN, SETTING, PARTICIPANTS, P < 0.01), with the relationship independent of the well-known risk factors, including age, diabetes, cardiovascular disease history, and inflammation and malnutrition markers. Moreover, comparisons of the risk in key subgroups showed that the risk of high fatigue score for cardiovascular events was more prominent in well-nourished patients, including lower age, absence of past cardiovascular diseases, higher serum albumin, and high non-HDL cholesterol. CONCLUSIONS: Fatigue can be an important predictor for cardiovascular events in patients with ESRD, with the relationship independent of the nutritional or inflammatory status.
Koyama et al. (Fri,) conducted a cohort in End-Stage Renal Disease (ESRD) undergoing hemodialysis (n=788). High fatigue score (>2 SD above healthy mean) vs. Normal fatigue score (≤2 SD above healthy mean) was evaluated on Fatal or nonfatal cardiovascular events (HR 2.17, 95% CI 1.23-3.85, p=0.008). High fatigue scores in patients undergoing hemodialysis independently predicted a significantly higher risk for fatal or nonfatal cardiovascular events (HR 2.17) compared to normal fatigue scores.