Albumin in the priming solution resulted in a significantly lower platelet count drop (-4.8%) compared to Carmeda coating (11.0%) and uncoated oxygenators (20.3%) during cardiopulmonary bypass.
RCT (n=60)
Randomly divided
Does surface coating or albumin priming reduce platelet count drop during cardiopulmonary bypass in patients undergoing open-heart surgery?
Adding albumin to the priming solution of an uncoated oxygenator significantly reduces platelet count drop during cardiopulmonary bypass compared to Carmeda coating or no coating.
Absolute Event Rate: -4.8% vs 20.3%
This study was designed to investigate the effect of surface coating on platelet count drop during cardiopulmonary bypass (CPB). Sixty patients undergoing open-heart surgery were randomly divided into three groups each receiving a different type of coated hollow-fiber membrane oxygenator. The patients were given either an uncoated oxygenator (noncoated group), an oxygenator coated with Carmeda (Carmeda group) or an uncoated oxygenator with albumin in the priming solution (albumin group). Comparisons were made in platelet count pre-CPB, on bypass (15-25 min) and during the warming period. Calculations were used to account for the effect of hemodilution. The albumin group had significantly lower platelet count drops (-4.8+/-7.1%) than the Carmeda group (11.0+/-8.3%) and the noncoated group (20.3+/-14.5%). Carmeda surface coating demonstrated some beneficial effects, but to a lesser degree than the albumin.
Palanzo et al. (Sat,) conducted a rct in Open-heart surgery requiring cardiopulmonary bypass (n=60). Albumin in priming solution or Carmeda-coated oxygenator vs. Uncoated oxygenator was evaluated on Platelet count drop. Albumin in the priming solution resulted in a significantly lower platelet count drop (-4.8%) compared to Carmeda coating (11.0%) and uncoated oxygenators (20.3%) during cardiopulmonary bypass.
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