Targeted cancer therapeutics can cause cardiotoxicity, often manifesting as dilated cardiomyopathy, due to shared signaling pathways between tumorigenesis and cardiomyocyte survival.
Understanding the shared signaling pathways between cancer and cardiac hypertrophy provides insight into the molecular mechanisms of cardiotoxicity from targeted cancer therapeutics.
In 2002, Hoshijima and Chien drew largely theoretical parallels between the dysregulation of the signaling pathways driving cancer and those driving cardiac hypertrophy (Hoshijima M, Chien KR. J Clin Invest. 2002;109:849-855). On the surface, this statement appeared to stretch the limits of reason, given the fact that cancer cells are known for their proliferative capacity, and adult cardiomyocytes are, except under unusual circumstances, terminally differentiated and incapable of re-entering the cell cycle. However, on closer examination, there are numerous parallels between signaling pathways that drive tumorigenesis and signaling pathways that regulate hypertrophic responses and survival in cardiomyocytes. Indeed, this issue appears to be at the core of the cardiotoxicity (often manifest as a dilated cardiomyopathy) that can result from treatment with agents typically referred to as "targeted therapeutics," which target specific protein kinases that are dysregulated in cancer. Herein, we examine the cardiotoxicity of targeted therapeutics, focusing on the underlying molecular mechanisms, thereby allowing an understanding of the problem but also allowing the identification of novel, and sometimes surprising, roles played by protein kinases in the heart.
Cheng et al. (Thu,) conducted a review in Cardiovascular toxicity. Targeted cancer therapeutics was evaluated. Targeted cancer therapeutics can cause cardiotoxicity, often manifesting as dilated cardiomyopathy, due to shared signaling pathways between tumorigenesis and cardiomyocyte survival.