Does the degree of coronary microvascular dysfunction predict clinical deterioration and death in patients with hypertrophic cardiomyopathy?
Patients with hypertrophic cardiomyopathy
Coronary microvascular dysfunction (exposure)
Clinical deterioration and deathhard clinical
Severe microvascular dysfunction is a strong independent predictor of adverse outcomes in hypertrophic cardiomyopathy, identifying high-risk patients even before symptom onset.
In patients with hypertrophic cardiomyopathy, the degree of microvascular dysfunction is a strong, independent predictor of clinical deterioration and death. Severe microvascular dysfunction is often present in patients with mild or no symptoms and may precede clinical deterioration by years.
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Franco Cecchi
Iacopo Olivotto
Roberto Gistri
New England Journal of Medicine
Imperial College London
Hammersmith Hospital
Istituto di Fisiologia Clinica
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Cecchi et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69dcebd2d111c0385b359927 — DOI: https://doi.org/10.1056/nejmoa025050
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