A review of calcium signaling in developing cardiomyocytes highlights the progressive maturation of calcium homeostasis and its regression to an immature state in pathophysiological conditions.
Understanding the developmental physiology of calcium signaling in cardiomyocytes is crucial for interpreting data from immature models like stem cells and understanding pathophysiological regression.
Adult cardiomyocytes exhibit complex Ca(2+) homeostasis, enabling tight control of contraction and relaxation. This intricate regulatory system develops gradually, with progressive maturation of specialized structures and increasing capacity of Ca(2+) sources and sinks. In this review, we outline current understanding of these developmental processes, and draw parallels to pathophysiological conditions where cardiomyocytes exhibit a striking regression to an immature state of Ca(2+) homeostasis. We further highlight the importance of understanding developmental physiology when employing immature cardiomyocyte models such as cultured neonatal cells and stem cells.
Louch et al. (Wed,) conducted a review in Cardiomyocyte development and disease. Calcium signalling was evaluated. A review of calcium signaling in developing cardiomyocytes highlights the progressive maturation of calcium homeostasis and its regression to an immature state in pathophysiological conditions.