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The lack of antifungal compounds with reduced side effects highlights the importance of studying natural products for this purpose. Curcumin was a more potent antifungal than fluconazole against P. brasiliensis, the causal agent of the neglected disease paracoccidioidomycosis. Curcumin dramatically inhibited the adhesion of Candida species isolated from AIDS patients to BEC, demonstrating that curcumin is a promising lead compound that warrants further investigation into its therapeutical use in immunocompromised patients.
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C. V. B. Martins
Danielle L. da Silva
Ana Tereza Neres
Journal of Antimicrobial Chemotherapy
Universidade Federal de Minas Gerais
Universidade Estadual do Oeste do Paraná
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Martins et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69d74ec3c74376700bf31431 — DOI: https://doi.org/10.1093/jac/dkn488