Does co-administration of ketoconazole or diltiazem increase apixaban exposure?
Co-administration of apixaban with ketoconazole or diltiazem increases apixaban exposure, highlighting important drug-drug interactions.
A 2-fold and 1.4-fold increase in apixaban exposure was observed with co-administration of ketoconazole and diltiazem, respectively.
Frost et al. (Thu,) studied this question.