Abnormal preprocedural cTnT independently predicted long-term death after nonemergency PCI (HR 1.79; 95% CI 1.35-2.39; P<0.001), whereas PCI-related myonecrosis predicted only short-term risk.
Cohort (n=5,487)
No
Effect estimate: HR 9.66 (95% CI 2.30-40.57)
Absolute Event Rate: 2.3% vs 0.1%
p-value: p=0.002
Background— Myonecrosis after percutaneous coronary intervention (PCI) has been correlated with a worse prognosis, but controversy exists about the clinical significance and potential mechanisms for the association. The aim of this study was to evaluate the relative impact of preprocedural and postprocedural cardiac troponin T (cTnT) levels on survival rate after PCI. Methods and Results— We evaluated 5487 patients from the Mayo Clinic registry who required nonemergency PCI, and we examined the relationship between periprocedural cTnT levels, with the 99th percentile cutoff value used for normal (0.01 is a powerful independent predictor of prognosis after PCI and is of greater prognostic significance than the postprocedural biomarker levels. PCI-related myonecrosis occurs frequently and predicts short-term but not long-term risk of death.
Prasad et al. (Fri,) conducted a cohort in Patients requiring nonemergency PCI (n=5,487). Abnormal preprocedural cTnT level vs. Normal preprocedural and postprocedural cTnT levels was evaluated on 30-day mortality (HR 9.66, 95% CI 2.30-40.57, p=0.002). Abnormal preprocedural cTnT independently predicted long-term death after nonemergency PCI (HR 1.79; 95% CI 1.35-2.39; P<0.001), whereas PCI-related myonecrosis predicted only short-term risk.
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