Two-dimensional strain analysis showed minimum right ventricular lateral systolic strain in Brugada syndrome was lower than controls (-28.9% vs -32.3%, P=0.002) but greater than ARVD/C (-24.6%).
Observational (n=65)
Does two-dimensional strain analysis detect right ventricular abnormalities in patients with Brugada syndrome compared to controls and ARVD/C patients?
Two-dimensional strain echocardiography can detect mild right ventricular systolic and diastolic abnormalities in Brugada syndrome patients, which are intermediate in severity between healthy controls and ARVD/C patients.
Absolute Event Rate: -28.9% vs -32.3%
p-value: p=0.002
AIMS: Brugada syndrome (BrS) is an inherited channelopathy that can be characterized by mild right ventricular (RV) abnormalities that are not detectable with conventional echocardiography. The aim of this study was to evaluate the presence of RV abnormalities in BrS patients when compared with controls and a group of patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) using two-dimensional (2D) strain analysis. METHODS AND RESULTS: We enrolled 25 BrS, 15 ARVD/C patients, and 25 controls. Right and left ventricular dimension and systo-diastolic function were evaluated by conventional echocardiography. Longitudinal systolic strain (sS) peak, systolic and early diastolic strain rate of lateral RV segments were evaluated by 2D speckle tracking analysis. Left ventricle global and segmental strain measures were also evaluated. A reduced basal or mid-RV lateral sS were the parameters mostly associated with both BrS and ARVD/C. In BrS patients the minimum sS observed in these segments was significantly lower than that of controls (-28.9±3.2% vs. -32.3±3.2%, P: 0.002) but significantly greater than that evaluated in ARVD/C patients (-24.6±6.7%, P<0.001 both vs. BrS and controls). No differences were found between the BrS and the control group when left ventricular strain measures were analysed. CONCLUSION: By 2D strain technique it is possible to observe mild abnormalities in RV systolic and diastolic function of BrS patients that are less pronounced than those observed in ARVD/C patients. These results help to better define the phenotypic characteristics of BrS patients and represent the basis for future studies aimed at testing their clinical usefulness in BrS patients.
Iacoviello et al. (Tue,) conducted a observational in Brugada syndrome and arrhythmogenic right ventricular dysplasia/cardiomyopathy (n=65). Two-dimensional (2D) strain analysis vs. Controls and ARVD/C patients was evaluated on Minimum longitudinal systolic strain (sS) of basal or mid-RV lateral segments (p=0.002). Two-dimensional strain analysis showed minimum right ventricular lateral systolic strain in Brugada syndrome was lower than controls (-28.9% vs -32.3%, P=0.002) but greater than ARVD/C (-24.6%).
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