Diastolic strain rate during dobutamine infusion identified segments with >20% transmural infarction and correlated with the extent of interstitial fibrosis (r = -0.86, P < 0.01).
Effect estimate: r = -0.86
p-value: p=< 0.01
We sought to assess the role of regional diastolic function by Doppler echocardiography in predicting myocardial viability. Sixteen dogs underwent left anterior descending coronary artery (n = 8) or circumflex (n = 8) occlusion. All animals were imaged at baseline and 1-8 wk postinfarction (post-MI). In 10 dogs, invasive hemodynamic monitoring with a conductance catheter placed in the left ventricle (LV) was performed at the above time points. Dobutamine was infused at 1-8 wk post-MI to determine LV contractile reserve. Histomorphological analysis was performed to determine the presence of viable myocardium and changes in interstitial matrix. Post-MI, diastolic strain rate measurements (in radial and longitudinal planes) decreased significantly in the distribution of the diseased artery (P 20% transmural infarction and related best to the extent of interstitial fibrosis (r = -0.86, P < 0.01). In an animal model of healing canine infarcts, diastolic strain rate by Doppler echocardiography appears to be a promising novel index of myocardial viability.
Park et al. (Fri,) conducted a other in Myocardial infarction (n=16). Diastolic strain rate by Doppler echocardiography was evaluated on Extent of interstitial fibrosis (r = -0.86, p=< 0.01). Diastolic strain rate during dobutamine infusion identified segments with >20% transmural infarction and correlated with the extent of interstitial fibrosis (r = -0.86, P < 0.01).
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