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(18)F-FE-PE2I is a promising PET radioligand for quantifying DAT. The binding potentials could be reliably estimated in both the striatum and midbrain using both the indirect kinetic and SRTM methods with a scan duration of 60 min. Although radiometabolites of (18)F-FE-PE2I in plasma possibly introduced some effects on the radioactivity in the brain, the effects on estimated binding potential were likely to be small.
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Takeshi Sasaki
Hiroshi Ito
Yasuyuki Kimura
Journal of Nuclear Medicine
Karolinska Institutet
Karolinska University Hospital
Tokyo Medical and Dental University
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Sasaki et al. (Mon,) studied this question.
www.synapsesocial.com/papers/69dabde64a1e15904c836012 — DOI: https://doi.org/10.2967/jnumed.111.101626