Phylogenetic analysis of theiloviruses classifies them into five types (TMEV, VHEV, TRV, SAFV-1, and SAFV-2) and suggests the existence of theiloviruses that cause human central nervous system infections.
Phylogenetic analysis of theiloviruses suggests the existence of strains that cause human central nervous system infections and classifies them into five distinct types.
The Cardiovirus genus of the family Picornaviridae includes two distinct species, Encephalomyocarditis virus and Theilovirus. We now report the complete nucleotide sequences of three Theiler's murine encephalomyelitis virus (TMEV) strains (TO Yale, TOB15, and Vie 415HTR) and of Vilyuisk human encephalomyelitis virus (VHEV). This information, together with the recently reported sequences of divergent theiloviruses (Theiler's-like rat virus TRV and Saffold viruses 1 and 2 SAFV-1 and SAFV-2), enables an updated phylogenetic analysis as well as a reexamination of several gene products important in the pathogenesis of this emerging group of viruses. In the light of the known neurotropism of TMEV and the new human SAFV-1 and SAFV-2, the resulting data suggest the existence of theiloviruses that cause human central nervous system infections. Our phylogenetic analyses point to the classification of presently known theiloviruses into five types: TMEV, VHEV, TRV, SAFV-1, and SAFV-2.
Liang et al. (Thu,) conducted a other in Theilovirus infection. Complete genome sequencing and phylogenetic analysis was evaluated. Phylogenetic analysis of theiloviruses classifies them into five types (TMEV, VHEV, TRV, SAFV-1, and SAFV-2) and suggests the existence of theiloviruses that cause human central nervous system infections.