Cardiac screening uptake was significantly greater than genetic testing uptake among at-risk relatives of mutation-positive cardiomyopathy probands (57% vs 39%; p<0.0001).
Observational (n=302)
No
What is the uptake of cardiac screening and genetic testing among at-risk relatives of patients with hypertrophic and dilated cardiomyopathy?
In families with hypertrophic and dilated cardiomyopathy, the uptake of cascade cardiac screening (57%) is significantly higher than genetic testing (39%), highlighting a gap in the implementation of guideline recommendations.
Absolute Event Rate: 57% vs 39%
p-value: p=<0.0001
Cardiomyopathy is a genetically and clinically heterogeneous, life threatening disease which affects people of all ages. Recent guidelines provide recommendations for cardiac screening and genetic testing in at-risk relatives, but the uptake and impact of these measures in the United States is unknown. This is a single institution retrospective study that characterizes the uptake of cardiac screening and genetic testing for relatives of a cohort of 57 probands with hypertrophic (HCM) and dilated cardiomyopathy (DCM) who underwent both clinical evaluation and genetic testing. Cardiac screening was indicated for 302 relatives. One hundred and seventy-three (57 %) completed cardiac screening. Forty of the 57 probands were mutation positive and genetic testing was indicated for 213 relatives. Eighty-four (39 %) completed genetic testing. The uptake of cardiac surveillance was greater than the uptake of genetic testing (p < 0.0001) among relatives of mutation positive probands. Within the group of at-risk, asymptomatic relatives of probands, cardiac screening and genetic testing were positive in 25 % and 40 % of cases, respectively. These data demonstrate the important role and utility of cascade cardiac screening and genetic testing in the care of patients and families with HCM or DCM. The approach to cardiac screening and genetic testing should be family-specific and requires expertise in the genetics of cardiomyopathy.
Miller et al. (Tue,) conducted a observational in Hypertrophic and Dilated Cardiomyopathy (n=302). Cardiac screening vs. Genetic testing was evaluated on Uptake of screening/testing among relatives of mutation positive probands (p=<0.0001). Cardiac screening uptake was significantly greater than genetic testing uptake among at-risk relatives of mutation-positive cardiomyopathy probands (57% vs 39%; p<0.0001).