Animal models for atrial fibrillation research are reviewed, detailing the principal mechanisms governing atrial arrhythmias in each model and providing guidelines for model selection.
This review provides a comprehensive overview of animal models used in atrial fibrillation research and offers guidelines for selecting appropriate models for specific research purposes.
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. A variety of animal models have been used to study the pathophysiology of AF, including molecular basis, ion-current determinants, anatomical features, and macroscopic mechanisms. In addition, animal models play a key role in the development of new therapeutic approaches, whether drug-based, molecular therapeutics, or device-related. This article discusses the various types of animal models that have been used for AF research, reviews the principle mechanisms governing atrial arrhythmias in each model, and provides some guidelines for model selection for various purposes.
Nishida et al. (Thu,) conducted a review in Atrial fibrillation. Animal models was evaluated. Animal models for atrial fibrillation research are reviewed, detailing the principal mechanisms governing atrial arrhythmias in each model and providing guidelines for model selection.