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Weak instrument bias is of practical importance for the design and analysis of Mendelian randomization studies. Post hoc choice of instruments, genetic models or data based on measured F-statistics can exacerbate bias. In particular, the commonly cited rule of thumb that F > 10 avoids bias in IV analysis is misleading.
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Burgess et al. (Wed,) studied this question.
www.synapsesocial.com/papers/695b0048f64facd5757672a3 — DOI: https://doi.org/10.1093/ije/dyr036
Stephen Burgess
Simon G. Thompson
International Journal of Epidemiology
MRC Biostatistics Unit
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