Oxygen administration diminished apnea-induced oxygen desaturations during Cheyne-Stokes respiration, but hemodynamic alterations persisted.
Observational (n=10)
Does oxygen administration alter the hemodynamic and cerebral circulatory changes associated with Cheyne-Stokes respiration in patients with heart failure or previous stroke?
Cheyne-Stokes respiration involves phase-linked cyclic changes in cerebral, respiratory, and cardiovascular functions that persist despite oxygen administration, suggesting they are generated by variations in central nervous activity rather than blood gas alterations alone.
Because cardiovascular disorders and stroke may induce Cheyne-Stokes respiration, our purpose was to study the interaction among cerebral activity, cerebral circulation, blood pressure, and blood gases during Cheyne-Stokes respiration. Ten patients with heart failure or a previous stroke were investigated during Cheyne-Stokes respiration with recordings of daytime polysomnography, cerebral blood flow velocity, intra-arterial blood pressure, and intra-arterial oxygen saturation with and without oxygen administration. There were simultaneous changes in wakefulness, cerebral blood flow velocity, and respiration with accompanying changes in blood pressure and heart rate approximately 10 s later. Cerebral blood flow velocity, blood pressure, and heart rate had a minimum occurrence in apnea and a maximum occurrence during hyperpnea. The apnea-induced oxygen desaturations were diminished during oxygen administration, but the hemodynamic alterations persisted. Oxygen desaturations were more severe and occurred earlier according to intra-arterial measurements than with finger oximetry. It is not possible to explain Cheyne-Stokes respiration by alterations in blood gases and circulatory time alone. Cheyne-Stokes respiration may be characterized as a state of phase-linked cyclic changes in cerebral, respiratory, and cardiovascular functions probably generated by variations in central nervous activity.
Franklin et al. (Wed,) conducted a observational in Cheyne-Stokes respiration (n=10). Oxygen administration vs. Without oxygen administration was evaluated on Interaction among cerebral activity, cerebral circulation, blood pressure, and blood gases. Oxygen administration diminished apnea-induced oxygen desaturations during Cheyne-Stokes respiration, but hemodynamic alterations persisted.