Relatives carrying an Ryr2 mutation (associated with Catecholaminergic Polymorphic Ventricular Tachycardia)
Phenotypic diversity and arrhythmic event rate
Relatives carrying an Ryr2 mutation exhibit marked phenotypic diversity but generally experience a low rate of arrhythmic events during follow-up.
Relatives carrying an Ryr2 mutation show a marked phenotypic diversity. The vast majority do not have signs of supraventricular disease manifestations. Mutation location may be associated with severity of the phenotype. The arrhythmic event rate during follow-up was low.
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Christian van der Werf
Ineke Nederend
Nynke Hofman
Circulation Arrhythmia and Electrophysiology
Radboud University Nijmegen
University of Groningen
University Medical Center Groningen
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Werf et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69d573c85883a1e80be3bc34 — DOI: https://doi.org/10.1161/circep.112.970517
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