Percutaneous left atrial appendage occlusion in patients with atrial fibrillation demonstrated a 93% implantation success rate and an overall stroke incidence of 1.4% per annum.
Systematic Review
Does percutaneous left atrial appendage occlusion (PLAAO) safely prevent stroke in patients with atrial fibrillation?
PLAAO is a relatively safe procedure for stroke prevention in AF patients, with high implantation success and low annual stroke rates.
This review aims to evaluate systematically the safety and efficacy of percutaneous left atrial appendage occlusion (PLAAO) in stroke prevention for patients with atrial fibrillation (AF). A systematic review of peer-reviewed journals on PLAAO before June 2011 was performed on three electronic databases. Fourteen studies were identified for evaluation. Overall, implantation was successful in 93% of all cases. Periprocedural mortality and stroke rates were 1.1% and 0.6%, respectively. The incidences of pericardial effusion/cardiac tamponade and device embolisation were 4% and 0.7%, respectively. At the time of the latest follow-up (up to 40 months), the overall incidence of stroke among all studies was 1.4% per annum. Existing evidence suggests that PLAAO is a relatively safe treatment for patients with AF. However, there is a need for further evaluation of its efficacy in the form of large and well-designed randomised controlled trials.
Munkholm-Larsen et al. (Tue,) conducted a systematic review in Atrial fibrillation. Percutaneous left atrial appendage occlusion (PLAAO) was evaluated on Stroke incidence. Percutaneous left atrial appendage occlusion in patients with atrial fibrillation demonstrated a 93% implantation success rate and an overall stroke incidence of 1.4% per annum.