January 1, 1998
View Full PaperBeta-Adrenergic Blockade in Chronic Heart Failure
Structured PICO
Does beta-adrenergic blockade improve LV function and survival in patients with chronic heart failure?
P
Population
Patients with chronic heart failure
I
Intervention
Beta-adrenergic blockade
O
Outcome
LV function, chamber characteristics, and survival
Beta-blockers are a promising treatment for chronic heart failure that may improve LV function and survival, pending confirmation from Phase III trials.
Abstract
In summary, beta-blockade is currently the most promising "new" treatment undergoing Phase III testing in chronic heart failure. Multiple studies on the effects of these agents on LV function and chamber characteristics as well as limited survival data strongly suggest that these agents produce a beneficial effect on the natural history of heart failure. If this promise is borne out in the currently active or planned large-scale clinical trials, this form of therapy will emerge as the most valuable treatment available for chronic heart failure.