Are higher serum phosphorus levels associated with increased arterial stiffness in individuals without clinical CVD?
Higher serum phosphorus levels are strongly associated with peripheral arterial stiffness (high ABI) in individuals without clinical CVD, suggesting a potential mechanism for phosphorus-related cardiovascular risk.
BACKGROUND AND OBJECTIVES: Higher phosphorus levels are associated with cardiovascular disease (CVD) events and mortality. Whether vascular stiffness may be responsible is unknown. DESIGN, SETTING, PARTICIPANTS, 95% confidence interval 1.6 to 13.2; P = 0.01) after adjustment for demographics, traditional CVD risk factors, and kidney function. Higher phosphorus levels were also associated with greater pulse pressure and lesser large and small artery elasticity in unadjusted models, but these associations were attenuated after adjustment. CONCLUSIONS: Higher phosphorus levels are strongly associated with high ABI but not pulse pressure or large or small artery elasticity. If confirmed in future studies, then the association of higher phosphorus concentrations with CVD events may be partially mediated through peripheral arterial stiffness.
Ix et al. (Thu,) studied this question.
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