NK Cell Compartments and Their Activation by Dendritic Cells

Introduction In recent years, it has been realized that innate lymphocytes do not act in isolation but potentiate their efficiency by interacting with each other, resulting even in the regulation of adaptive immune response. One such cross-talk exists between dendritic cells (DCs) and natural killer (NK) cells. Here, we summarize recent studies on which subsets of these two innate immune components in this interaction, how it influences immune, and to which extent similar stimuli are integrated DCs and NK cells during innate immunity. We suggest that this cross-talk should be harnessed by activating both of these innate leucocyte populations with new adjuvant formulations for immunotherapies.