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BACKGROUND: Thyroid-stimulating hormone (TSH) is used to detect primary hypo- and hyperthyroidism. Current guidelines for TSH assays recommend a functional sensitivity of 0.2 mIU/L also showed method differences. The ARCHITECT i2000 method was the most precise at low TSH concentrations. CONCLUSIONS: TSH methods do not provide comparable results for serum pools with TSH concentrations <0.2 mIU/L or for patient results across the analytic measurement range. Further investigation into the cause of these differences and additional harmonization efforts are required.
Rawlins et al. (Fri,) studied this question.