Obstructive sleep apnoea was associated with impaired endothelial function compared to non-obese subjects without OSA (FMD% 6.4 vs 10.1; p=0.003), independently of obesity.
Cross-Sectional (n=71)
No
Is obstructive sleep apnoea associated with endothelial dysfunction independently of obesity?
Obstructive sleep apnoea is associated with impaired endothelial function independently of obesity, suggesting a direct link between OSA and early atherosclerotic changes.
Absolute Event Rate: 6.4% vs 10.1%
p-value: p=0.003
OBJECTIVE: Obstructive sleep apnoea (OSA) and obesity are both associated with endothelial dysfunction, which precedes the development of atherosclerosis. As obesity is highly prevalent in OSA, we wanted to test the hypothesis that OSA is associated with endothelial dysfunction independently of obesity. DESIGN: Cross-sectional, population-based study. SETTING: Norwegian university hospital. PATIENTS: Seventy-one subjects (median age 44 years, 35% female) were recruited from a population-based study in Norway. Participants were categorised as obese (body mass index (BMI) ≥30 kg/m(2)), non-obese (BMI<30 kg/m(2)) with OSA (apnoea-hypopnoea index (AHI)≥10), or non-obese without OSA (AHI<5). INTERVENTIONS: None. MAIN OUTCOME MEASURES: Endothelial function measured by brachial artery ultrasound and expressed as percentage of flow-mediated dilation (FMD%). RESULTS: When non-obese subjects without OSA were used as the reference (FMD% (mean±SD) 10.1±6.3), endothelial function was found to be impaired in subjects with OSA (FMD% 6.4±3.2) (p=0.003). FMD% did not differ between obese (6.0±3.4) and non-obese (6.7±3.1) OSA subjects (p=0.3). By univariate linear regression analysis, AHI, BMI, gender and baseline brachial artery diameter were significantly associated with FMD%. When these variables were entered into a multivariate model, only AHI was significantly associated with FMD%. CONCLUSIONS: OSA is associated with endothelial dysfunction independently of obesity and conventional risk factors.
Namtvedt et al. (Tue,) conducted a cross-sectional in Obstructive sleep apnoea (n=71). Obstructive sleep apnoea vs. Non-obese subjects without OSA was evaluated on Endothelial function expressed as percentage of flow-mediated dilation (FMD%) (p=0.003). Obstructive sleep apnoea was associated with impaired endothelial function compared to non-obese subjects without OSA (FMD% 6.4 vs 10.1; p=0.003), independently of obesity.
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