A single hemodialysis session significantly increased QT dispersion in patients with chronic renal failure from 63.1 ms to 76.6 ms (P<0.01), which was already higher than controls (36.0 ms; P<0.001).
Observational (n=70)
Does a single hemodialysis session increase QT dispersion in patients with chronic renal failure?
Hemodialysis significantly increases QT dispersion, which may explain the elevated risk of reentrant arrhythmias and sudden cardiac death in the immediate postdialysis period.
Absolute Event Rate: 76.6% vs 63.1%
p-value: p=< 0.01
Sudden cardiac death is common in patients on hemodialysis, and may occur in the immediate postdialysis period, when ventricular premature complexes are common. Elevated QT dispersion (Maximum - Minimum QT interval on standard 12-lead electrocardiogram) is associated with increased risk of ventricular arrhythmias following myocardial infarction, but has not previously been assessed in patients with chronic renal failure. We studied electrocardiograms recorded in 50 patients before and after a single hemodialysis session, and in 20 control subjects. QT dispersion was significantly higher in patients (63.1 +/- 20.6 ms) compared with control subjects (36.0 +/- 13.7 ms; P < 0.001) and rose significantly after hemodialysis to levels comparable to those seen following myocardial infarction (76.6 +/- 27.0 ms; P < 0.01). Because QT dispersion reflects nonhomogeneous recovery of ventricular excitability, hemodialysis patients may be at significantly greater risk of reentrant arrhythmias and sudden death in the postdialysis period.
Morris et al. (Fri,) conducted a observational in Chronic renal failure (n=70). Hemodialysis vs. Pre-hemodialysis state and control subjects was evaluated on QT dispersion (p=< 0.01). A single hemodialysis session significantly increased QT dispersion in patients with chronic renal failure from 63.1 ms to 76.6 ms (P<0.01), which was already higher than controls (36.0 ms; P<0.001).