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Reduced connectivity within frontoparietal control systems and imbalanced connectivity between control systems and networks involved in internal or external attention may reflect depressive biases toward internal thoughts at the cost of engaging with the external world. Meanwhile, altered connectivity between neural systems involved in cognitive control and those that support salience or emotion processing may relate to deficits regulating mood. These findings provide an empirical foundation for a neurocognitive model in which network dysfunction underlies core cognitive and affective abnormalities in depression.
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Roselinde H. Kaiser
Jessica R. Andrews‐Hanna
Tor D. Wager
JAMA Psychiatry
Harvard University
University of Colorado Boulder
McLean Hospital
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Kaiser et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69d5753e5f8349d3f7ad502a — DOI: https://doi.org/10.1001/jamapsychiatry.2015.0071