A history of pre-eclampsia or eclampsia was associated with a fourfold increased risk for hypertension, a twofold increased risk for ischemic heart disease, stroke, and DVT, and 1.5-times higher mortality.
Meta-Analysis
Does a history of pre-eclampsia or eclampsia increase the risk of future cardiovascular disease, cancer, and all-cause mortality in women?
A history of pre-eclampsia or eclampsia is associated with significantly increased risks of future cardiovascular disease and all-cause mortality, suggesting these women may benefit from early preventive therapies.
Effect estimate: 4-fold increased risk for hypertension
Evaluation of: Bellamy L, Casas JP, Hingorani AD, Williams DJ: Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. Br. Med. J. 335(7627), 974 (2007). Evidence has emerged over the years suggesting that women who develop hypertensive pregnancy disorders, most notably pre-eclampsia, are at an increased risk for cardiovascular disease later in life. In this study, a systematic review and meta-analysis were performed, assessing the future risks of cardiovascular disease, cancer and all-cause mortality in women with a history of pre-eclampsia and eclampsia. Women with a history of pre-eclampsia or eclampsia, compared with women without such a history, had an increased risk for cardiovascular disease, including a fourfold increased risk for hypertension, a twofold increased risk for ischemic heart disease, stroke and deep venous thrombosis, and a 1.5-times higher all-cause mortality. The study suggests that affected women may be eligible for preventive therapies at an earlier age, especially if future studies establish the role of pre-eclampsia as an independent cardiovascular risk factor.
Craici et al. (Sat,) conducted a meta-analysis in Pre-eclampsia and eclampsia. History of pre-eclampsia or eclampsia vs. Women without a history of pre-eclampsia or eclampsia was evaluated on Future risks of cardiovascular disease, cancer and all-cause mortality (4-fold increased risk for hypertension). A history of pre-eclampsia or eclampsia was associated with a fourfold increased risk for hypertension, a twofold increased risk for ischemic heart disease, stroke, and DVT, and 1.5-times higher mortality.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: