Do ACE inhibitors and beta-blockers reduce mortality in heart failure patients with and without renal insufficiency?
ACE inhibitors and beta-blockers provide similar mortality benefits in heart failure patients regardless of the presence of renal insufficiency.
Renal insufficiency is more prevalent in patients with heart failure than previously reported and is an independent prognostic factor in diastolic and systolic dysfunction. ACE inhibitors and beta-blockers were associated with similar reductions in mortality in patients with and without renal insufficiency.
McAlister et al. (Tue,) studied this question.