Does the measurement of LDL-C, lipoprotein(a), and HDL-C levels in children from FH families allow accurate diagnosis and identification of highest CVD risk kindreds?
Children in familial hypercholesterolemia (FH) families/kindreds
Measurement of LDL-C, lipoprotein(a), and HDL-C levels
Diagnosis of FH and identification of highest cardiovascular disease (CVD) risk kindredssurrogate
Lipid profiling in children from FH families is crucial for early diagnosis and identifying kindreds at the highest cardiovascular risk.
In FH families, LDL-C levels allow accurate diagnosis of FH in childhood. Moreover, increased LDL-C and lipoprotein(a) and decreased HDL-C levels in children identify FH kindreds with the highest CVD risk.
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Albert Wiegman
Pediatric Cardiology
Jessica Rodenburg
Cincinnati Children's Hospital Medical Center
Saskia de Jongh
Amsterdam UMC Location University of Amsterdam
Circulation
Erasmus University Rotterdam
Erasmus MC
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Wiegman et al. (Mon,) studied this question.
synapsesocial.com/papers/69d73a2eef4aa71f97f308ec — DOI: https://doi.org/10.1161/01.cir.0000058166.99182.54