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Significance The role of the cell cycle as an inhibitor of the late stages of cellular differentiation is well known, but in early embryonic development its role is mysterious. Normally, embryonic stem (ES) cells proliferate quickly during differentiation and do not differentiate simply by cell cycle slowing. In this paper, it is shown that the role of the cell cycle in terminal stages of differentiation can be adapted for and extended into ES cells. Methods aimed at inhibiting the cell cycle drive a rapid, condensed differentiation to terminally differentiated cells, demonstrating that the cell cycle is a principle rate-limiting step of differentiation throughout early and late stages. This is beneficial as well for accelerating differentiation in ES cell applications.
Li et al. (Mon,) studied this question.
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