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Metabolic sensors such as AMPK and SIRT1, gatekeepers of the activity of the master regulator of mitochondria, PGC-1alpha, are vital links in a regulatory network for metabolic homeostasis. Together, these players explain many of the beneficial effects of physical activity and dietary interventions in our battle against type 2 diabetes and related metabolic disorders. Hence, understanding the mechanisms by which they act could guide us to identify and improve preventive and therapeutic strategies for metabolic diseases.
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Carles Cantó
Johan Auwerx
Current Opinion in Lipidology
École Polytechnique Fédérale de Lausanne
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Cantó et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69d8ca3a270e68ba94bed857 — DOI: https://doi.org/10.1097/mol.0b013e328328d0a4