PET imaging revealed that the global mismatch score of cardiac sympathetic function was significantly greater in ischemic CHF patients than in healthy volunteers (50.3 vs 19.3, P=0.005).
Observational (n=38)
Does PET imaging of pre- and postsynaptic cardiac sympathetic function identify a mismatch in patients with ischemic congestive heart failure compared to healthy volunteers?
Patients with severe ischemic CHF exhibit a significant mismatch between pre- and postsynaptic left ventricular sympathetic function, which may be associated with adverse clinical outcomes.
Absolute Event Rate: 50.3% vs 19.3%
p-value: p=0.005
UNLABELLED: Pre- and postsynaptic cardiac sympathetic function is altered in ischemic congestive heart failure (CHF). Whether there is a presynaptic-to-postsynaptic mismatch or whether mismatch is related to adverse cardiac events is unknown. METHODS: In 13 patients with ischemic CHF and 25 aged-matched healthy volunteers, presynaptic function was measured by PET of (11)C-meta-hydroxyephedrine ((11)C-mHED), a norepinephrine (NE) analog. Postsynaptic function, beta-adrenergic receptor (BAR) density (B'(max)), was measured by imaging (11)C-CGP12177. Myocardial blood flow (MBF) was measured by imaging (15)O-water. Each heart was analyzed both globally and regionally, excluding infarcted regions, and a mismatch score, defined as the ratio of B'(max) to NE uptake (PS(nt))(,) was used to indicate mismatch of post- and presynaptic function. RESULTS: Global and regional MBF was not different between CHF and healthy subjects. The global measure of PS(nt) was lower in CHF (0.32 +/- 0.34) than that in healthy subjects (0.81 +/- 0.33, P 3 times that of the healthy subjects or the CHF patients without an adverse outcome. CONCLUSION: Mismatch between pre- and postsynaptic left ventricular sympathetic function is present in patients with severe CHF and may be more marked in those with adverse outcomes.
Caldwell et al. (Wed,) conducted a observational in Ischemic congestive heart failure (n=38). PET imaging of pre- and postsynaptic cardiac sympathetic function vs. Aged-matched healthy volunteers was evaluated on Global mismatch score (ratio of B'max to NE uptake) (p=0.005). PET imaging revealed that the global mismatch score of cardiac sympathetic function was significantly greater in ischemic CHF patients than in healthy volunteers (50.3 vs 19.3, P=0.005).