Higher ambulatory systolic blood pressure was associated with increased risks of subsequent renal (HR 1.17-1.28, P<0.001) and cardiovascular outcomes (HR 1.22-1.32, P<0.001).
Observational (n=617)
Effect estimate: HR 1.17-1.28 (renal); HR 1.22-1.32 (cardiovascular)
p-value: p=<0.001
BACKGROUND AND OBJECTIVES: Abnormal ambulatory BP (ABP) profiles are commonplace in CKD, yet the prognostic value of ABP for renal and cardiovascular outcomes is uncertain. This study assessed the relationship of baseline ABP profiles with CKD progression and subsequent cardiovascular outcomes to determine the prognostic value of ABP beyond that of clinic BP measurements. DESIGN, SETTING, PARTICIPANTS, P<0.001) and cardiovascular outcomes (hazard ratio, 1.22-1.32; P<0.001). After controlling for clinic SBP, ABP measures were predictive of renal outcomes in participants with clinic SBP <130 mmHg (P<0.05 for interaction). ABP predicted cardiovascular outcomes with no interaction based on clinic BP control. CONCLUSIONS: ABP provides additional information beyond that of multiple clinic BP measures in predicting renal and cardiovascular outcomes in African Americans with hypertensive CKD. The primary utility of ABP in these CKD patients was to identify high-risk individuals among those patients with controlled clinic BP.
Gabbai et al. (Fri,) conducted a observational in Hypertensive CKD (n=617). Higher ambulatory systolic BP was evaluated on Composite of doubling of serum creatinine, ESRD, or death (renal); composite of MI, hospitalized CHF, stroke, revascularization, CV death, and ESRD (cardiovascular) (HR 1.17-1.28 (renal); HR 1.22-1.32 (cardiovascular), p=<0.001). Higher ambulatory systolic blood pressure was associated with increased risks of subsequent renal (HR 1.17-1.28, P<0.001) and cardiovascular outcomes (HR 1.22-1.32, P<0.001).