Effect of Treating Isolated Systolic Hypertension on the Risk of Developing Various Types and Subtypes of StrokeThe Systolic Hypertension in the Elderly Program (SHEP)

Structured PICO

Does antihypertensive drug treatment reduce the incidence of stroke in elderly patients with isolated systolic hypertension?

Population

Elderly patients with isolated systolic hypertension

Intervention

Antihypertensive drug treatment targeting specific systolic blood pressure goals

Outcome

Incidence of various types and subtypes of stroke (hemorrhagic and ischemic, including lacunar)hard clinical

Treating isolated systolic hypertension to specific blood pressure goals reduces the risk of both hemorrhagic and ischemic strokes in the elderly.

Abstract

In this study, antihypertensive drug treatment reduced the incidence of both hemorrhagic and ischemic (including lacunar) strokes. Reduction in stroke incidence occurred when specific systolic blood pressure goals were attained. JAMA. 2000;284:465-471

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