Recent systolic blood pressure (HR 1.31; 95% CI 1.11-1.55) and BMI (HR 1.15; 95% CI 1.08-1.23) in midlife were associated with increased risk of incident heart failure in later life.
Cohort (n=3,362)
Do antecedent blood pressure and BMI in midadulthood affect the future development of incident heart failure in later life?
Higher blood pressure and BMI in midlife are independently associated with an increased risk of developing heart failure in later life, highlighting the importance of early risk factor modification.
Effect estimate: HR 1.31 (95% CI 1.11 to 1.55)
p-value: p=<0.001
Higher blood pressure and body mass index (BMI) are risk factors for heart failure. It is unknown whether the presence of these risk factors in midadulthood affect the future development of heart failure. In the community-based Framingham Heart Study, we examined the associations of antecedent blood pressure and BMI with heart failure incidence in later life. We studied 3362 participants (57% women; mean age: 62 years) who attended routine examinations between 1969 and 1994 and examined their systolic and diastolic blood pressure, pulse pressure, and BMI at current (baseline), recent (average of readings obtained 1 to 10 years before baseline), and remote (average of readings obtained 11 to 20 years before baseline) time periods. During 67 240 person-years of follow-up, 518 participants (280 women) developed heart failure. Current, recent, and remote systolic pressure; pulse pressure; and BMI were individually associated with incident heart failure (all P<0.001). Recent systolic pressure (hazards ratio HR per 1-SD increment: 1.31; 95% CI: 1.11 to 1.55), pulse pressure (HR per 1-SD increment: 1.33; 95% CI: 1.14 to 1.54), and BMI (HR per unit increase: 1.15; 95% CI: 1.08 to 1.23) were associated with heart failure risk even after adjusting for current measures. Similarly, remote systolic pressure (HR per 1 SD: 1.17; 95% CI: 1.04 to 1.31), pulse pressure (HR per 1 SD: 1.17; 95% CI: 1.06 to 1.31), and BMI (HR per unit: 1.09; 95% CI: 1.05 to 1.14) remained associated with incident heart failure after adjusting for current measurements. Higher blood pressure and BMI in midlife are harbingers of increased risk of heart failure in later life. Early risk factor modification may decrease heart failure burden.
Lee et al. (Mon,) conducted a cohort in Incident heart failure (n=3,362). Antecedent blood pressure and BMI vs. Current measurements was evaluated on Incident heart failure (HR 1.31, 95% CI 1.11 to 1.55, p=<0.001). Recent systolic blood pressure (HR 1.31; 95% CI 1.11-1.55) and BMI (HR 1.15; 95% CI 1.08-1.23) in midlife were associated with increased risk of incident heart failure in later life.
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