Preoperative exposure to renin-angiotensin system antagonists significantly increased the incidence of a clinically significant systolic pressure gradient (>10 mmHg) between radial and femoral arteries after cardiopulmonary bypass (69% vs 27%, p<0.001).
Cohort (n=85)
Absolute Event Rate: 69% vs 27%
p-value: p=<0.001
Background: Femoral to radial arterial pressure gradient (P) often develops after cardiopulmonary bypass (CPB) where radial artery pressure (RAP) does not reflect the actual perfusion pressure. Renin-angiotensin system antagonists (RAS-A) are increasingly prescribed preoperatively which causes vasodilation and vascular remodeling. We evaluated the effect of RAS-A medication on P after CPB in patients undergoing valvular heart surgery.
Kim et al. (Mon,) conducted a cohort in Valvular heart disease with regurgitant lesions (n=85). Preoperative Renin-Angiotensin System Antagonists (RAS-A) vs. Control group (not on RAS-A) was evaluated on Development of systolic pressure gradient (∆P) > 10 mmHg between femoral and radial artery after cardiopulmonary bypass (p=<0.001). Preoperative exposure to renin-angiotensin system antagonists significantly increased the incidence of a clinically significant systolic pressure gradient (>10 mmHg) between radial and femoral arteries after cardiopulmonary bypass (69% vs 27%, p<0.001).