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Thioacetamide, adapted to weekly weight changes, leads to a homogenous, reproducible model of cirrhosis in the rat in 18 weeks, which is associated with all the typical characteristics of portal hypertension, including endothelial dysfunction.
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Wim Laleman
Ingrid Vander Elst
Marcel Zeegers
European Journal of Clinical Investigation
KU Leuven
Universitair Ziekenhuis Leuven
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Laleman et al. (Fri,) studied this question.
www.synapsesocial.com/papers/69dbf49b08d4cb8205a3c167 — DOI: https://doi.org/10.1111/j.1365-2362.2006.01620.x