Compared with controls, male CHD patients had significantly lower concentrations of large LpA-I alpha(1) (-35%) and pre-alpha(1-3) particles, and higher small LpA-I/A-II alpha(3) particles (P<0.001).
Case-Control (n=155)
Are there differences in the distribution of ApoA-I-containing HDL subpopulations between male patients with coronary heart disease and healthy controls?
Patients with coronary heart disease exhibit a major rearrangement in HDL subpopulations, characterized by lower large LpA-I particles and higher small LpA-I/A-II particles, independent of total HDL-C levels.
p-value: p=<0.001
High density lipoproteins (HDLs) and their subspecies play a role in the development of coronary heart disease (CHD). HDL subpopulations were measured by 2-dimensional nondenaturing gel electrophoresis in 79 male control subjects and 76 male CHD patients to test the hypothesis that greater differences in apolipoprotein (apo)A-I-containing HDL subpopulations would exist between these 2 groups than for traditional lipid levels. In CHD subjects, HDL cholesterol (HDL-C) was lower (-14%, P35 mg/dL). Therefore, we stratified participants according to HDL-C concentrations into low and normal groups. The differences in lipid levels between controls and HDL-C-matched cases substantially decreased; however, the significant differences in HDL subspecies remained. Our research findings support the concept that compared with control subjects, CHD patients not only have HDL deficiency but also have a major rearrangement in the HDL subpopulations with significantly lower alpha(1) and pre-alpha(1-3) (LpA-I) and significantly higher alpha(3) (LpA-I/A-II) particles.
Asztalos et al. (Fri,) conducted a case-control in Coronary Heart Disease (n=155). Coronary Heart Disease vs. Control subjects was evaluated on Differences in apolipoprotein (apo)A-I-containing HDL subpopulations (p=<0.001). Compared with controls, male CHD patients had significantly lower concentrations of large LpA-I alpha(1) (-35%) and pre-alpha(1-3) particles, and higher small LpA-I/A-II alpha(3) particles (P<0.001).