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The effect of endogenous CO 2 from exercising muscles and exogenous CO 2 from CO 2 inhalation was investigated in six pairs of cross-circulated dogs. The exercising hindlimbs of one dog (neural) were perfused exclusively from a second dog (humoral). The ventilatory response of the neural dog during exercise followed the predicted isometabolic hyperbola toward hyperventilation, whereas the ventilation of the humoral dog followed closely the relationship which existed between V and PaCO CO2 during CO 2 inhalation. When the neural dog was given CO 2 mixtures during steady state of induced exercise, its ventilation increased in a rectilinear function of the PaCO CO2 . The V, PaCO CO2 line intersects the isometabolic curve for the exercise level at a PaCO CO2 close to the resting PaCO CO2 . A metabolic acidosis developed in the humoral dog, although the blood flow to the perfused hindlimbs appeared to be adequate during muscular exercise. cross perfusion; neural control of respiration; humoral control of respiration; CO 2 inhalation; muscle blood flow in exercise; perfusion of leg muscle Submitted on February 19, 1964
Kao et al. (Sun,) studied this question.