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The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.
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Crispin T. Hiley
University College London Hospitals NHS Foundation Trust
Elza C. de Bruin
AstraZeneca (United Kingdom)
Nicholas McGranahan
London Cancer
Genome biology
University College London
Cancer Research UK
Institute of Cancer Research
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Hiley et al. (Tue,) studied this question.
synapsesocial.com/papers/6a0cc9ec17d56fa39a4a4bba — DOI: https://doi.org/10.1186/s13059-014-0453-8