Does GH replacement therapy improve metabolic and auxological parameters in children with GH deficiency?
GH replacement therapy in children with GH deficiency improves final height and metabolic profiles without adversely affecting glucose metabolism.
In GHD children, the evaluation of metabolic parameters proves to be a useful tool for the evaluation of auxological parameters during GH replacement therapy. In our study, GH replacement therapy in GHD children improved final height, restored IGF-I levels, reduced leptin levels, and improved the lipid profile, without producing any unfavorable effects on glucose metabolism.
Ciresi et al. (Sat,) studied this question.