Late intervention and stenting of the LAD ~1 month post-AMI resulted in greater LV end-systolic volume at 12 months compared to medical therapy alone (106.6 vs 79.7 ml, p<0.01).
RCT (n=66)
Does late intervention and stenting of the LAD improve left ventricular end-systolic volume in symptom-free patients with persistent LAD occlusion after anterior AMI?
Late recanalization of an occluded LAD in symptom-free patients approximately 1 month post-AMI adversely affects left ventricular remodeling, despite potential improvements in exercise tolerance and quality of life.
Absolute Event Rate: 106.6% vs 79.7%
p-value: p=<0.01
OBJECTIVE: We sought to conduct a randomized trial comparing late revascularization with conservative therapy in symptom-free patients after acute myocardial infarction (AMI). BACKGROUND: In the absence of ischemia, the benefits of reperfusion late after AMI remain controversial. However, the possibility exists that an open infarct related artery benefits healing post AMI. METHODS: Of 223 patients enrolled with Q-wave anterior AMI, 66 with isolated persistent occlusion of the left anterior descending coronary artery (LAD) were randomized to the following treatments: 1) medical therapy (closed artery group; n = 34) or 2) late intervention and stent to the LAD + medical therapy (open artery group; n = 32). The study was powered to compare left ventricular (LV) end-systolic volume between the two groups 12 months post AMI. RESULTS: Late intervention 26 +/- 18 days post AMI resulted in significantly greater LV end-systolic and end-diastolic volumes at 12 months than medical therapy alone (106.6 +/- 37.5 ml vs. 79.7 +/- 34.4 ml, p < 0.01 and 162.0 +/- 51.4 ml vs. 130.1 +/- 46.1 ml, p < 0.01, respectively). Exercise duration and peak workload significantly increased in both groups from 6 weeks to 12 months post AMI, although absolute values were greater in the open artery group. Quality of life scores tended to deteriorate during this time interval in the closed artery patients but remained unchanged in the open artery patients. Coronary angiography at 1 year documented a low incidence of intergroup cross-over (spontaneous recanalization in 19% and closure in 11%). CONCLUSIONS: In the present study, recanalization of occluded infarct-related arteries in symptom-free patients approximately 1 month post AMI had an adverse effect on remodeling but tended to increase exercise tolerance and improve quality of life.
Yousef et al. (Sun,) conducted a rct in Acute myocardial infarction (n=66). Late intervention and stent to the LAD + medical therapy vs. Medical therapy alone was evaluated on Left ventricular end-systolic volume at 12 months post AMI (p=<0.01). Late intervention and stenting of the LAD ~1 month post-AMI resulted in greater LV end-systolic volume at 12 months compared to medical therapy alone (106.6 vs 79.7 ml, p<0.01).
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