Serum GGT concentration was positively associated with brachial-ankle pulse wave velocity in women (β=0.11; 95% CI 0.02-0.19; p<0.05), but not in men, independent of fatty liver and other covariates.
Cross-Sectional (n=912)
No
Is serum γ-glutamyltranspeptidase (GGT) associated with brachial-ankle pulse wave velocity (baPWV) in Japanese adults?
Serum GGT levels are independently associated with increased arterial stiffness (measured by baPWV) in Japanese women, but not in men.
Effect estimate: β 0.11 (95% CI 0.02 to 0.19)
p-value: p=<0.05
OBJECTIVE: The purpose of this study was to determine the relationship between serum γ-glutamyltranspeptidase (GGT) and brachial-ankle pulse wave velocity (baPWV) as an indicator for atherosclerosis in Japanese men and women after adjusting for fatty liver. DESIGN: A cross-sectional study. SETTING: A health check-up centre in Japan. PARTICIPANTS: 912 Japanese men and women aged 24-84 years recruited from people who received a medical health check-up programme with a standardised questionnaire and an automatic waveform analyser to measure baPWV. MAIN OUTCOME MEASURES: We measured serum GGT concentrations and baPWV. Fatty liver was diagnosed by standardised criteria using abdominal ultrasonography. The postmenopausal state was defined as beginning 1 year after the cessation of menses. RESULTS: In women, log2 GGT was positively associated with baPWV (β=0.11, 95% CI 0.02 to 0.19, p<0.05), independent of age, body mass index, systolic blood pressure, fasting plasma glucose, triglycerides, estimated glomerular filtration rate, fatty liver, menopausal state and parameters of lifestyles. However, in men, the positive association of log2 GGT with baPWV was not significant (β=-0.04, 95% CI -0.10 to 0.03, p=0.28) in multivariable linear regression analyses. CONCLUSIONS: The serum GGT level was associated with baPWV, independently of covariates including fatty liver or menopausal state just in women, but not in men.
Fukuda et al. (Wed,) conducted a cross-sectional in atherosclerosis (n=912). Serum γ-glutamyltranspeptidase (GGT) was evaluated on brachial-ankle pulse wave velocity (baPWV) (β 0.11, 95% CI 0.02 to 0.19, p=<0.05). Serum GGT concentration was positively associated with brachial-ankle pulse wave velocity in women (β=0.11; 95% CI 0.02-0.19; p<0.05), but not in men, independent of fatty liver and other covariates.