Atrial fibrillation in 75-year-old subjects was associated with a significantly higher prevalence of undiagnosed diabetes mellitus compared to controls without atrial fibrillation (13.0% vs 3.7%, OR 3.86).
Case-Control (n=154)
No
Does atrial fibrillation and its duration associate with an increased prevalence of undiagnosed dysglycaemia in 75-year-old subjects?
Older patients with atrial fibrillation, especially those with a duration of 5 years or more, have a significantly higher prevalence of undiagnosed diabetes and dysglycaemia, warranting proactive screening.
Effect estimate: OR 3.86 (95% CI 1.01, 16.25)
Absolute Event Rate: 13% vs 3.7%
p-value: p=0.031
BACKGROUND: The prevalence of atrial fibrillation (AF) is increasing world wide and amongst factors that aggravate the risk is diabetes mellitus (DM), also in epidemic development.However, although DM is a potentially modifiable risk factor for AF, few, if any, studies have explored the prevalence of undiagnosed dysglycaemia among subjects with AF or if duration of AF are related to parameters of glycaemia or dysglycaemia prevalence. METHODS: In this case control study, amongst 75-year old subjects with and without AF, the prevalence of dysglycaemia, i.e., impaired fasting glycaemia, impaired glucose tolerance or DM, according to World Health Organisation criteria was assessed by a 75-g oral glucose tolerance test (OGTT). RESULTS: Prevalence of undiagnosed DM among the 108 subjects (male/female 73/35, BMI 25.4 +/- 3.2) without and the 46 (male/female 34/12, BMI 25.3 +/- 3.7) with AF (median AF duration five years) where 3.7% and 13.0%, respectively (p = 0.031, Odds ratio (OR) 3.86 (95% Confidence interval CI: 1.01, 16.25)) whereas the overall prevalence of dysglycaemia (prediabetes and DM) where similar (respectively 43.5% and 39.1%, p = 0.46, OR 0.83 95% CI: 0.41, 1.69). Patients with AF duration >or= 5 years had however a higher dysglycaemia prevalence (61.1% DM 22.2%, prediabetes 38.9%) as compared to AF duration or= 5 years.
Johansen et al. (Tue,) conducted a case-control in Atrial fibrillation (n=154). Atrial fibrillation vs. No atrial fibrillation was evaluated on Prevalence of undiagnosed diabetes mellitus (OR 3.86, 95% CI 1.01, 16.25, p=0.031). Atrial fibrillation in 75-year-old subjects was associated with a significantly higher prevalence of undiagnosed diabetes mellitus compared to controls without atrial fibrillation (13.0% vs 3.7%, OR 3.86).