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Mutations in either the EGFR TK domain or the KRAS gene can lead to lung cancer pathogenesis. EGFR TK domain mutations are the first molecular change known to occur specifically in never smokers.
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Hisayuki Shigematsu
Lin Li
Tsuyoshi Takahashi
JNCI Journal of the National Cancer Institute
The University of Texas MD Anderson Cancer Center
The University of Texas Southwestern Medical Center
Fred Hutch Cancer Center
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Shigematsu et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69da11319a6164e50fa3db8c — DOI: https://doi.org/10.1093/jnci/dji055