The “Complex‐in‐a‐Complex” Cations (acac)2M⊂Ru6(p‐iPrC6H4Me)6(tpt)2(dhbq)36+: A Trojan Horse for Cancer Cells

The start of an odyssey? The cytotoxicities of the large cationic arene–ruthenium prismatic cage 16+, and its “complex-in-a-complex” derivatives (acac) 2M⊂16+ (M=Pd, Pt; acac=acetylacetonate; see picture), are evaluated in comparison with free M (acac) 2. The differences in cytotoxicity suggest that, like a “Trojan Horse”, leaching of the guest from the cage once inside a cell accelerates and increases the cytotoxic effect. Supporting information for this article is available on the WWW under http: //www. wiley-vch. de/contents/jc₂002/2008/z800186ₛ. pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.