The high-sensitivity troponin T assay at the 99th percentile cut-off demonstrated a sensitivity of 92.2% for diagnosing non-ST-segment myocardial infarction by two hours after presentation.
Observational (n=939)
Single-blind
Yes
Does early measurement with high-sensitivity troponin T assay improve diagnosis and prognostic utility compared to conventional assays in patients presenting with chest pain?
High-sensitivity troponin T assays provide earlier detection of myocardial injury and better prognostic information than conventional assays in patients with chest pain.
or novel cardiac markers to be clinically useful in diagnosing acute coronary syndromes, they need to show their incremental utility beyond that of existing markers, with therapeutic implications designed to improve patient care. Recent improvement in the performance of troponin assays to comply with current guidelines for the diagnosis of acute myocardial infarction 1 has resulted in a new generation of assays with enhanced clinical sensitivity that are now available for use in clinical care. Assays with high sensitivity have been shown to detect myocardial injury earlier 2-8 and identify more patients at risk of future adverse outcomes 8-10 than conventional assays.
Aldous et al. (Mon,) conducted a observational in Chest pain without ST-segment elevation (n=939). High-sensitivity troponin T assay vs. Conventional troponin I assay was evaluated on Diagnosis of non-ST-segment elevation myocardial infarction on admission (95% CI 88.1%-95.0%). The high-sensitivity troponin T assay at the 99th percentile cut-off demonstrated a sensitivity of 92.2% for diagnosing non-ST-segment myocardial infarction by two hours after presentation.